Medchemexpress LLC Mln120b dihydrochloride | 1782573-78-7 | C19H17Cl3N4O2 | 50 MG

Supplier:  Medchemexpress LLC HY15473A50MG

MLN120B dihydrochloride is a potent, orally active IKKβ inhibitor (IC50 60 nM) that inhibits multiple myeloma cell growth in vitro and in vivo. It is also used for rheumatoid arthritis research. In vitro, it blocks IκB phosphorylation/degradation and TNF-a-induced p65 NF-κB phosphorylation, reducing proliferation in various multiple myeloma cell lines. In vivo, oral administration reduces tumor growth markers and protects against bone and cartilage destruction in rheumatoid arthritis models.

• Potent, ATP competitive, orally active IKKβ inhibitor.
• Inhibits IκB phosphorylation and degradation.
• Blocks TNF-a-induced p65 NF-κB phosphorylation.
• Reduces proliferation of multiple myeloma cells.
• Inhibits IL-6 secretion from BMSCs.
• Protects against bone and cartilage destruction in rheumatoid arthritis models.
• Prolongs survival in treated animals.

Catalog No. 50-003-76210