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Medchemexpress LLC Pevonedistat | 905579-51-3 | 99.98% | C21H25N5O4S | 200 MG
Supplier: Medchemexpress LLC HY70062200MG
Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor. It acts by inducing deregulation of S-phase DNA synthesis, which disrupts protein turnover mediated by cullin-RING ligase, ultimately leading to apoptosis in human tumor cells. It also suppresses the growth of human tumor xenografts in mice.
- Potent and selective NEDD8-activating enzyme (NAE) inhibitor
- Induces deregulation of S-phase DNA synthesis
- Disrupts protein turnover mediated by cullin-RING ligase
- Promotes apoptosis of human tumor cells
- Suppresses tumor xenograft growth in mice
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