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AdipoGen MLN4924
SDP

Supplier:  AdipoGen AGCR13703M005

Encompass_Preferred

Chemical. CAS 905579-51-3. Formula C21H25N5O4S . H2O. MW 443.5 . 18.0. Adenosine 5-monophosphate AMP analog. Potent, selective and cell permeable inhibitor of Nedd8 E1 Activating Enzyme NAE IC50=4.7nM. NEDD8 is an ubiquitin-like protein whose activity is required to activate cullin-RING ubiquitin E3 ligases CRLs responsible for the ubiquitination and proteasome-dependent turnover of certain substrates relevant to cancer cell survival. Anticancer agent with in vitro and in vivo activity. By inhibiting the Neddylation pathway this molecule disrupts cullin-RING ligase activity, leading to inhibition of proliferation or apoptotic death of various human tumor cells through the deregulation of S-phase DNA synthesis. Inhibits related enzymes ubiquitin-activating enzyme UAE and SUMO-activating enzyme SAE with IC50 values of 1.5 and 8.2µM, respectively. Angiogenesis inhibitor and autophagy inducer. Antiviral agent.

Catalog No. 50-256-2198


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