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Apexbio Technology LLC MLN8054 869363-13-3 200mg
Supplier: Apexbio Technology LLC A4114200
MLN8054 (CAS 869363-13-3) is a small-molecule inhibitor targeting Aurora A kinase (AAK) It exhibits ATP-competitive reversible inhibition and demonstrates high selectivity for AAK with an IC50 of 4 nM showing 40-fold and 100-fold greater selectivity over Aurora B kinase and other kinases respectively In cellular studies MLN8054 impairs AAK function leading to inactivation of the protein Pt288 disruption of mitotic spindle formation G2/M phase cell cycle arrest and induction of apoptosis In preclinical tumor xenograft models MLN8054 has demonstrated antitumor activity This compound is widely utilized in research focused on cell cycle regulation mitosis and the therapeutic targeting of cancer
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