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Medchemexpress LLC Momelotinib sulfate | 1056636-06-6 | 99.9% | 610.62 | 1 ML
Supplier: Medchemexpress LLC HY10962100MG
Momelotinib sulfate is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 values of 11 nM and 18 nM, respectively. It exhibits 10-fold selectivity versus JAK3 (IC50=155 nM). It inhibits the growth of Ba/F3-JAK2V617F and human erythroleukemia (HEL) cells.
- Inhibits JAK1 and JAK2
- Shows selectivity over JAK3
- Inhibits the growth of certain leukemia cells
- Administered orally in preclinical studies
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