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Medchemexpress LLC Momelotinib (sulfate) | 1056636-06-6 | 99.9% | 610.62 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY1096210MG

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Momelotinib sulfate (CYT387 sulfate salt) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, showing 10-fold selectivity versus JAK3 (IC50=155 nM). It inhibits the growth of Ba/F3-JAK2V617F and human erythroleukemia (HEL) cells (IC50=1.5 μM) or Ba/F3-MPLW515L cells (IC50=200 nM), but has considerably less activity against BCR-ABL harboring K562 cells (IC50=58 μM) and FLT3 mutation harboring MV4-11 cells (IC50=3 μM). Proliferation of parental Ba/F3 cells (Ba/F3-wt) stimulated with IL-3 is inhibited with an IC50 value of 1.4 μM.

  • ATP-competitive inhibitor of JAK1/JAK2
  • Selective for JAK1/JAK2 over JAK3
  • Available in solid and solution forms
  • Suitable for research use

Catalog No. 50-003-44727


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