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Medchemexpress LLC Momelotinib sulfate | 1056636-06-6 | 99.91% | 610.62 | 10 MG
Supplier: Medchemexpress LLC HY1096250MG
Momelotinib sulfate is an ATP-competitive inhibitor of JAK1/JAK2, demonstrating high selectivity over JAK3. It effectively inhibits the growth of various cell lines, including Ba/F3-JAK2V617F and human erythroleukemia (HEL) cells, with less activity against BCR-ABL harboring K562 cells and FLT3 mutation harboring MV4-11 cells.
- Target: JAK1 (IC50=11 nM), JAK2 (IC50=18 nM), JAK3 (IC50=155 nM)
- Appearance: Solid, light yellow to yellow color
- Solubility in DMSO: 120 mg/mL
- Solubility in H2O: 100 mg/mL
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