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Apexbio Technology LLC Monastrol 329689-23-8 10mg
Supplier: Apexbio Technology LLC B607510
Monastrol (CAS 329689-23-8) is a cell-permeable small molecule inhibitor that selectively targets the mitotic kinesin Eg5 a motor protein essential for bipolar spindle formation in cell division Monastrol impedes microtubule motility mediated by Eg5 resulting in mitotic arrest without affecting progression through S or G2 phases or centrosome duplication In vitro it demonstrates an IC50 of 14 M for Eg5 inhibition and induces reversible mitotic arrest with chromosomes attached to microtubules extending from centrosomes Monastrol is widely utilized in cell biology research to probe spindle assembly mechanisms and investigate mitotic kinesin function
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