U-Blot Pan-Mono/Di-Methyllysine Rabbit pAb is a Rabbit-derived polyclonal antibody that specifically recognizes Mono/Di-Methyllysine It shows reactivity with Human Mouse Rat Validated applications include WB Recommended dilutions WB 1500-11000 Purified by protein a-conjugated agarose followed by methyllysine agarose affinity chromatography Histone post-translational modifications (PTMs) are key mechanisms of epigenetics that modulate chromatin structures termed as histone code The PTMs on histone including acetylation methylation phosphorylation and novel acylations directly affect the accessibility of chromatin to transcription factors and other epigenetic regulators altering genome stability gene transcription etc Histone methylation occurs primarily at lysine and arginine rsidues on the amino-terminal of core histones Supplied as 100 uL