Medchemexpress LLC Monobenzone | 103-16-2 | MFCD10687031 | 99.9% | 200.24 | 100 G

Supplier:  Medchemexpress LLC HY30272100G

Monobenzone is a potent skin depigmenting agent with potential for vitiligo research. It also acts as an inhibitor of RNR enzyme activity, targeting the RRM2 protein. This demonstrates significant anti-leukemia efficacy both in vitro and in vivo, by inhibiting acute myeloid leukemia (AML) cell proliferation and DNA synthesis, and inducing cell cycle arrest and apoptosis.

• Inhibits AML cell proliferation and DNA synthesis.
• Induces cell cycle arrest and apoptosis in various AML cell lines.
• Blocks DNA damage repair.
• Can overcome drug resistance in certain cell lines.
• Synergistically inhibits cell growth with Bcl-2 inhibitor.
• Induces skin depigmentation in mice.
• Effectively inhibits AML cell xenograft growth in nude mice with low toxicity.

Catalog No. 50-004-00480