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Medchemexpress LLC Monomethyl auristatin E | 474645-27-7 | C39H67N5O7 | 50 MG
Supplier: Medchemexpress LLC HY15162G50MG
Monomethyl auristatin E (MMAE) is a potent tubulin polymerization inhibitor. This product is produced following GMP guidelines and is intended for research use only. It has demonstrated significant biological activity in various cancer models, including its ability to enhance the effects of radiation therapy.
- Functions as a tubulin polymerization inhibitor.
- Effectively released within CD30+ cancer cells.
- Exerts cytotoxic activity on bystander cells.
- Sensitizes colorectal and pancreatic cancer cells to ionizing radiation.
- Correlates with mitotic arrest.
- Leads to tumor growth delay in vivo when combined with radiation.
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