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Apexbio Technology LLC Monomethyl auristatin E 474645-27-7 50mg
Supplier: Apexbio Technology LLC A363150
Monomethyl auristatin E (MMAE) is a highly potent antimitotic compound that exerts cytotoxic effects by inhibiting tubulin polymerization Microtubules play essential roles in various cellular processes including intracellular transport cell migration and mitotic chromosome segregation MMAE interrupts this process leading to cell cycle arrest and apoptosis MMAE is commonly utilized in preclinical and clinical studies as the cytotoxic payload in antibody-drug conjugates (ADCs) targeting tumor-specific antigens to selectively deliver cytotoxicity to cancer cells In vitro cell studies and in vivo tumor xenograft models show that antibody conjugation enables specific targeting resulting in reduced off-target toxicity and improved therapeutic index compared to unconjugated cytotoxic agents
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