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AdipoGen MPLA from S. minnesota R595 (Re) TLRpure Sterile Solution, 1 mg
Supplier: AdipoGen IAX100002M001
≥99.9%, No detectable DNA, RNA and protein traces. Synonyms: Monophosphoryl Lipid A (MPLA) derived from S. minnesota R595 (Re) TLRpure LPS (biosynthetic), Formulation: Liquid. Colourless opaque aqueous solution. Activation of cells by LPS is mediated by the Toll-like receptor 4 (TLR4), a member of the highly conserved protein family of TLRs, which are specialised in the recognition of microbial components. In mice, defects in TLR4 result in LPS unresponsiveness. For optimal interaction with LPS, TLR4 requires association with myeloid differentiation protein 2 (MD-2). According to current consensus activation of TLR4 is preceded by the transfer of LPS to membrane-bound (m) or soluble (s) CD14 by LPS-binding protein (LBP). This mechanism is believed to be generally true for LPS signaling.
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