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Cayman Chemical MosaprIdecItrate 10mg
Supplier: Cayman Chemical 3004810 MG
A 5-HT4 agonist (Ki = 69.9 nM); selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and α1- and α2-adrenergic receptors at 1 mM but also acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM); induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC50s = 208.4 and 73.2 nM, respectively); increases antral and duodenal, but not ileal or colonic, motility in conscious dogs at 0.5 and 1 mg/kg; increases gastric emptying in rats from 0.03-30 mg/kg
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