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Invitrogen™ Mouse BDNF ELISA Kit

Catalog No. EEL088
Encompass_Preferred
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Quantity:
96 Tests

ELISA

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P21237
Assay Range 31.25 to 2000 pg/mL
Assay Sensitivity 18.75 pg/mL
Conjugate HRP
Product Type ELISA
Sample Type Plasma, Serum
For Use With (Equipment) Colorimetric Microplate Reader
Gene ID (Entrez) 12064
Gene Symbol BDNF
Interassay CV <10%
Intraassay CV <10
Kit Contents Pre-coated 96 well plate, Standard, Biotinylated Detection Antibody, HRP Conjugate, Standard & Sample Diluent, Biotinylated Detection Antibody Diluent, HRP Conjugate Diluent, Wash Buffer, TMB Substrate, Stop Solution, Plate Sealer
Label or Dye HRP
Quantity 96 Tests
Regulatory Status RUO
Sample Volume Plasma 100 μL, Serum 100 μL
Storage Requirements Refer to product documentation for component specific storage temperature.
Target BDNF
Test Time 1 hrs 20 mins
Total Assay Time 3 hrs 30 mins
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