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Proteintech Group Inc Mouse DKK1 ELISA Kit 96well
Supplier: Proteintech Group Inc KE1003396T
Dickkopf 1 (DKK1), a foundational member of the Dickkopf proteins, has been identified as a naturally secreted glycoprotein that typically antagonizes the Wnt/β-catenin signaling pathway by sequestering the Wnt receptor complex LRP5/6 (PMID: 31335221). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PMID: 22738799).
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