Invitrogen™ Mouse IFN-alpha 2 Recombinant Protein, eBioscience™

Description

Recombinant Protein

IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.

Specifications

• Accession Number: P01573
• Concentration: 0.1 mg/mL
• For Use With (Application): Control, Functional Assay
• Formulation: 50 mM sodium acetate with 0.1 M NaCl, 1% BSA and no preservative; pH 5.0
• Gene ID (Entrez): 15965
• Molecular Weight (g/mol): 19.4 kDa
• Name: Mouse IFN-alpha 2
• pH Range: 5.0
• Purification Method: SDS-PAGE
• Quantity: 5 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <0.01 ng/ μg
• Gene Alias: alpha-2 A interferon; Ifa2; IFNA; IFN-a; IFNA 2; Ifna2; IFNA2A; IFNA2B; IFNA2C; IFN-alpha 1 b; IFN-alpha-1/13; IFN-alpha-2; IFN-alphaA; INFA2; Interferon; interferon alpha 1 b; interferon alpha 2; interferon alpha 2 A; interferon alpha 2 b; interferon alpha A; interferon alpha family, gene 2; interferon alpha-2; Interferon alpha-A; interferon alpha-D; interferon, alpha 2; Interferon-alpha II; leIF A; leIF D; RP11-354P17.2
• Common Name: Interferon alpha-2
• Gene Symbol: Ifna2
• Biological Activity: ED50 = 0.1 ng/mL; as measured by the inhibition of the cytopathic effect of EMC virus on L929 cells.
• Product Type: Recombinant Protein
• Conjugate: Unconjugated
• Species: E. coli
• Recombinant: Recombinant
• Sequence: Mature mouse IFN-alpha 2, amino acids Cys24-Glu190 (Accession # NM_010503)
• Content And Storage: -80°C
• Expression System: E. coli
• Form: Liquid
• Protein Subtype: Recombinant
• Purity or Quality Grade: >98% by SDS-PAGE

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov