Gibco™ Mouse IL-12 p80 Recombinant Protein, PeproTech®

Catalog No.	Quantity
21012P80H50	50 μg
21012P80H10	10 μg

Catalog No. 21012P80H50 Supplier Gibco™ Supplier No. 21012P80H50UG

Description

Recombinant Protein

210-12P80H-100UG will be provided as 2 x 50 μg (210-12P80H-50UG). 210-12P80H-1MG will be provided as 20 x 50 μg (210-12P80H-50UG). 210-12P80H-250UG will be provided as 5 x 50 μg (210-12P80H-50UG). 210-12P80H-500UG will be provided as 5 x 100 μg (210-12P80H-50UG). Recombinant Murine IL-12 p80 is an 80.0 kDa, disulfide linked homodimer of two p40 chains of IL-12 that consists of 626 amino acid residues and less than 5% of the IL-12 p40 monomer. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis.

IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicates that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or it can form the homodimer designated IL-12 p80. Elevated levels of IL-12 p80 correlate to macrophage recruitment and increased inflammation in asthma and respiratory viral infection models.

Specifications

• Accession Number: P43432
• For Use With (Application): Control, Bioactivity
• Formulation: Protein with no preservative
• Gene ID (Entrez): 16160
• Molecular Weight (g/mol): 80 kDa
• Name: Mouse IL-12 p80
• Purification Method: Purified
• Quantity: 50 μg
• Source: HEK293 cells
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/μg
• Gene Alias: IL-12; Interleukin
• Common Name: IL-12 p80
• Gene Symbol: IL12B
• Biological Activity: Determined by its ability to inhibit the proliferative effect of 2 ng/ml mIL-12 p70 in T cell-enriched PBMCs.
• Product Type: Protein
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: p40 subunit: MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGVIGSG KTLTITVKEF LDAGQYTCHK GGETLSHSHL LLHKKENGIW STEILKNFKN KTFLKCEAPN YSGRFTCSWL VQRNMDLKFN IKSSSSSPDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE TLPIELALEA RQQNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVEVS WEYPDSWSTP HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS
• Content And Storage: -20°C
• Activity: Determined by its ability to inhibit the proliferative effect of 2 ng/ml mIL-12 p70 in T cell-enriched PBMCs.
• Expression System: HEK293 cells
• Form: Lyophilized
• Purity or Quality Grade: ≥ 95% by SDS-PAGE gel and HPLC analyses.