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Gibco™ Mouse LIF Recombinant Protein

Catalog No. PMC9484
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PMC9484 10 μg
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Catalog No. PMC9484 Supplier Gibco™ Supplier No. PMC9484
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Description

Recombinant Protein

Storage: Store at -20°C to -80°C for 12 months, 1 month at 4°C after reconstituted or 3 months when stored at -20°C to -80°C after reconstituting as directed.

Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P09056
For Use With (Application) Bioactivity
Formulation PBS with 0.02% Tween 20 and no preservative
Gene ID (Entrez) 16878
Molecular Weight (g/mol) 20 kDa
Name Mouse LIF
Purification Method Purified
Quantity 10 μg
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration ≤1 EU/μg
Gene Alias CDF; cholinergic differentiation factor; cholinergic neuronal differentiation factor; d factor; DIA; differentiation inhibitory activity; differentiation-inducing factor; differentiation-stimulating factor; Emfilermin; hepatocyte-stimulating factor III; HILDA; human interleukin in DA cells; leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor); LIF; Melanoma-derived LPL inhibitor; MLPLI; myeloid leukaemia inhibitory factor
Common Name LIF
Gene Symbol Lif
Biological Activity ED50 ≤ 1 ng/mL; determined by the dose-dependent production of IL-6 in. M1 myeloid leukemic cells.
Product Type Protein
Conjugate Unconjugated
Species Mouse
Recombinant Recombinant
Sterility Sterile
Sequence Mouse LIF recombinant protein contains 181 amino acids
Content And Storage -20°C
Activity ED50 ≤ 1 ng/mL; determined by the dose-dependent production of IL-6 in M1 myeloid leukemic cells.
Bioassay Ability to induce IL-6 production in M1 myeloid leukemic cells
Shipping Condition Wet Ice
Expression System E. coli
Protein Family Cytokines & Receptors
Protein Form Recombinant, Ligand
Form Liquid
Protein Subtype Other Cytokines
Research Category Stem Cell Research, Oncology
Product Line Gibco
Purity or Quality Grade ≥95% by SDS-PAGE
Protein Leukemia inhibitory factor
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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