Invitrogen eBioscience Mouse MCPT-1 (mMCP-1) ELISA Ready-SET-Go! Kit
Optimized for the accurate and precise measurement of mouse MCPT-1 in serum, and tissue culture supernatant samples. MCPT-1 (Mast Cell Protease-1) is a β-chymase, a type of serine protease stored and secreted in a tissue-specific manner by mucosal mast cells.
Manufacturer: Invitrogen 88750386
DescriptionMCPT-1 is the only chymase expressed by intestinal mucosal mast cells, which are found in the intestinal epithelium. Although it is expressed constitutively and is detectable in the sera of normal mice, parasites in the gut cause systemic levels to increase dramatically within two days and peak at two weeks following infection. It plays an important role in host defense against intestinal parasites, as mice deficient in MCPT-1 display delayed response upon infection. Elevated MCPT-1 levels are also observed during intestinal allergic hypersensitivity reactions. The mechanism of its action is not fully understood, although it is believed to increase intestinal permeability similarly to rMCPT-II, possibly by cleaving the proteins at tight junctions between cells.
|Colorimetric Microplate Reader|
|1 hr 45 min|
|Mouse Mast Cell Protease-1|
|96-Well Plates: Corning Costar flat-bottom plated (included with catalog numbers ending in -22 and -86)|
|10 x 96 tests|
|Serum (100μL), Supernatants (100μL)|
|24 hr 30 min|
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