Invitrogen™ Mouse PCSK2 (aa 622-638) Synthetic Peptide

Catalog No.	Quantity
PEP138	50 μg

Catalog No. PEP138 Supplier Invitrogen™ Supplier No. PEP138

Description

Synthetic Peptide

PEP-138 is a 17 amino acid synthetic peptide whose sequences are derived from mouse PC2 protein. The sequence of this peptide is (amino to carboxy terminus): E (622)-L-D-E-A-V-E-R-S-L-Q-S-I-L-R-K-N (638). This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse PC2, catalog # PA1-058. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions. Reconstitute with 0.1 mL of distilled water.

The subtilisin-like prohormone convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. PC family members share structural similarities, which include a heterogeneous approximately 10 kDa amino-terminal proregion, a highly conserved approximately 55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. The subcellular localization of PC family members varies. Immunolocalization studies show that PC1 is found in the perinuclear region as well as the trans-Golgi network, whereas PC2 can be found in the trans-Golgi network as well as diffusely distributed in the peripheral cytoplasm.

Specifications

• Gene ID (Entrez): 18549
• Species: Mouse
• Purification Method: purified
• Accession Number: P21661
• Common Name: PCSK2
• Concentration: 0.5 mg/mL
• Content And Storage: -20°C. Avoid freeze-thaw cycles.
• Description: Synthetic Peptide
• Format: Lyophilized
• Formulation: Peptide with no preservative
• For Use With (Application): Control
• Gene Alias: 6330411F23Rik; AI839700; EC 3.4.21.94; KEX2-like endoprotease 2; NEC 2; NEC2; Nec-2; Neuroendocrine convertase 2; PC2; PC2-like protein; PCSK2; Phpp-2; Prohormone convertase 2; prohormone convertase 2-like protein; propotein convetase subtilisin/kesin type 2; proprotein convertase 2; proprotein convertase subtilisin/kexin type 2; proprotein convertase type 2; Rpc2; SPC2
• Gene Symbol: Pcsk2
• Lyophilized: Yes
• Preservative: No preservative
• Product Type: Peptide
• Quantity: 50 μg
• Regulatory Status: RUO
• Sequence: E(622)-L-D-E-A-V-E-R-S-L-Q-S-I-L-R-K-N(638)