Invitrogen™ Mouse PPAR alpha (aa 8-19) Synthetic Peptide

Catalog No.	Quantity
PEP181	50 μg

Catalog No. PEP181 Supplier Invitrogen™ Supplier No. PEP181

Description

Synthetic Peptide

PEP-181 is a 12 amino acid synthetic peptide whose sequence is derived from mouse PPAR alpha protein with serine 12 being phosphorylated. The sequence of this peptide is (amino to carboxy terminus): Synthetic Peptide: C-I (8)-C-P-L- (pS)-P-L-E-A-D-D-L (19) This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse phospho-PPAR alpha (Ser12), catalog # PA1-820. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions. Reconstitute with 0.1 mL of distilled water.

Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed peroxisome proliferator activated receptors (PPAR's). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPAR's are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPAR's can induce transcription of acyl coenzyme A oxidase & cytochrome P450 (CYP450) A6 through interaction with specific response elements. PPAR, like several other nuclear hormone receptors, heterodimerizes with retinoid X receptor (RXR) alpha.

Specifications

• Gene ID (Entrez): 19013
• Species: Mouse
• Purification Method: purified
• Accession Number: P23204
• Common Name: PPAR alpha
• Concentration: 0.5 mg/mL
• Content And Storage: -20°C. Avoid freeze-thaw cycles.
• Description: Synthetic Peptide
• Format: Lyophilized
• Formulation: Peptide with no preservative
• For Use With (Application): Control
• Gene Alias: 4933429D07Rik; AW742785; hPPAR; I79_022392; MGC2237; MGC2452; Nr1c1; nuclear hormone receptor; nuclear receptor; nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor alpha; peroxisome proliferative activated receptor, alpha; peroxisome proliferative activated receptor, alpha isoform 1; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor alpha; peroxisome proliferator-activated nuclear receptor alpha variant 3; peroxisome proliferator-activated receptor alpha; PPAR; PPAR ALPHA; Ppara; PPARALPHA; PPAR-alpha; proliferator-activated receptor alpha; transcription factor belonging to the nuclear receptor superfamily
• Gene Symbol: PPARA
• Lyophilized: Yes
• Preservative: No preservative
• Product Type: Peptide
• Quantity: 50 μg
• Regulatory Status: RUO
• Sequence: I(8)-C-P-L-(pS)-P-L-E-A-D-D-L(19)

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov