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STEMCELL Technologies Mouse Recombinant Flt3/Flk-2 Ligand, Size: 10 µg
Supplier: STEMCELL Technologies 78011.1
Modulate the proliferation, differentiation and survival of hematopoietic stem and progenitor cells with Flt3/Flk-2 Ligand (Hannum et al. Nature, 1994). Flt3/Flk-2 Ligand, in combination with stem cell factor and thrombopoietin, can promote the expansion of primitive CD34+ hematopoietic cells in culture (Hannum et al.). Together with different interleukins and cytokines, Flt3/Flk-2 Ligand can also be used to regulate the development of various lymphoid progenitor cells, including dendritic cell, B cell, T cell, and NK cell progenitors. While Flt3/Flk-2 Ligand is produced by a variety of cell types, the expression of its receptor is restricted to CD34+ hematopoietic stem and progenitor cells (Drexler & Quentmeier. Growth Factors, 2004). Mouse recombinant Flt3/Flk-2 Ligand from STEMCELL comes lyophilized with ≥ 95% purity; specific activity EC50 ≤ 10 ng/mL; endotoxin levels verified ≤ 1 EU/μg protein. Alternative names: FL, FLT3L, Flt3-L, Flt3 Ligand, Fms-like tyrosine kinase 3 ligand.
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