STEMCELL Technologies Mouse Recombinant IL-1 alpha, Size: 100 ug

Supplier:  STEMCELL Technologies 78129.1

Interleukin 1 alpha (IL-1a) is a member of the IL-1 family and a dual-function cytokine. Both the unprocessed precursor and a processed IL-1a protein signal through IL-1 receptor type 1 (IL-1R1). Various cells including keratinocytes thymic epithelium hepatocytes endothelial cells fibroblasts and the epithelial cells of mucous membranes have high levels of intracellular IL-1a precursor which is also expressed on the surface of monocytes and B lymphocytes (Netea et al.). IL-1a recruits infiltrating cells to a site of injury during necrosis and plays an important role during processes of sterile inflammation (Rider et al. Cohen et al.). During hypoxia IL-1a contributes to angiogenesis (Carmi et al.). IL-1a is produced by microglia-like cells after ischemic brain injury which contributes to the inflammation (Luheshi et al.).

Catalog No. 50-239-0163