STEMCELL Technologies Mouse Recombinant IL-10, Size: 10 µg

Supplier:  STEMCELL Technologies 78079

Use interleukin 10 (IL-10) to enhance B cell proliferation, immunoglobulin secretion, and class II MHC expression (Ouyang et al. Annu Rev Immunol, 2011). IL-10 is the founding member of the IL-10 family of class II cytokines, which have a four-helix bundle consisting of α-helical folds. Upon binding to its receptor, IL-10 activates signaling through JAK1 and STAT3. IL-10 is important for the function of T regulatory cells as it is a potent suppressor of effector T cell proliferation and cytokine production. It is produced by a number of immune cells, such as dendritic cells, macrophages, and CD4+ T regulatory cells, as well asmast cells, NK cells, and regulatory B cells, under specific stimulating conditions (Saraiva & O'Garra. Nat Rev Immunol, 2010). Mouse recombinant IL-10 from STEMCELL comes lyophilized with ≥ 95% purity; EC50 ≤ 0.2 ng/mL; endotoxin levels verified ≤ 0.2 EU/μg protein. Alternative names: B-TCGF, CSIF, Cytokine synthesis inhibitory factor, Interleukin-10, TGIF.

Catalog No. 50-197-6418

Safety and Handling

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