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STEMCELL Technologies Mouse Recombinant PDGF-BB, Size: 100 ug
Supplier: STEMCELL Technologies 78178.1
Use platelet-derived growth factor (PDGF) BB to induce mesenchymal stem cell migration angiogenesis and osteogenesis (Xie et al. Nat Med 2014). The PDGF family has five heparin-binding members that assemble into four homodimers (PDGF-AA PDGF-BB PDGF-CC and PDGF-DD) and one heterodimer (PDGF-AB) (Fretto et al. J Biol Chem 1993 Li Eriksson. Cytokine Growth Factor Rev 2003). This glycoprotein signals through the receptor tyrosine kinases PDGFRa and PDGFR. PDGF is a potent mitogen for cells of mesenchymal origin and induces migration through signaling pathways involving MEK/ERK EGFR Src and PI3K/AKT (Kim et al. Growth Factors 2007). PDGF-BB is secreted by osteoblasts and preosteoclasts during bone modeling and remodeling (Xie et al.). Mouse recombinant PDGF-BB from STEMCELL comes lyophilized with ≥ 95% purity EC50 2 ng/mL endotoxin levels verified 1 EU/μg protein. Alternative names GDGF ODGF Platelet-
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