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STEMCELL Technologies Mouse Recombinant PDGF-BB, Size: 10 µg
Supplier: STEMCELL Technologies 78178
Use platelet-derived growth factor (PDGF) BB to induce mesenchymal stem cell migration, angiogenesis, and osteogenesis (Xie et al. Nat Med, 2014). The PDGF family has five heparin-binding members that assemble into four homodimers (PDGF-AA, PDGF-BB, PDGF-CC, and PDGF-DD) and one heterodimer (PDGF-AB) (Fretto et al. J Biol Chem, 1993; Li & Eriksson. Cytokine Growth Factor Rev, 2003). This glycoprotein signals through the receptor tyrosine kinases PDGFRα and PDGFRβ. PDGF is a potent mitogen for cells of mesenchymal origin and induces migration through signaling pathways involving MEK/ERK, EGFR, Src, and PI3K/AKT (Kim et al. Growth Factors, 2007). PDGF-BB is secreted by osteoblasts and preosteoclasts during bone modeling and remodeling (Xie et al.). Mouse recombinant PDGF-BB from STEMCELL comes lyophilized with ≥ 95% purity; EC50 ≤ 2 ng/mL; endotoxin levels verified ≤ 1 EU/μg protein. Alternative names: GDGF, ODGF, Platelet-derived growth factor. Visit STEMCELL.com for more information.
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