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STEMCELL Technologies Mouse Recombinant TNF-alpha, Size: 100 ug
Supplier: STEMCELL Technologies 78069
Tumor necrosis factor-a (TNF-a) is a pro-inflammatory cytokine that activates NF-κB MAPK and PI3K/AKT pathways. Activated T cells and macrophages are the primary producers of TNF-a in response to inflammation and infectious conditions. Many other cell types have been shown to produce TNF-a among them B cells NK cells mast cells neutrophils dendritic cells microglia endothelial cells smooth muscle cells cardiomyocytes and fibroblasts. TNF-a has cytotoxic effects on cancer cells in vitro by stimulating anti-tumor immunosuppressive responses. TNF-a stimulates expression of E- and P-selectins thus facilitating adhesion of neutrophils monocytes and memory T cells to activated platelets and endothelial cells (Zelová amp Hosek). Other effects of TNF-a include vasodilatation and edema formation.
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