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Apexbio Technology LLC MPC 6827 hydrochloride 917369-31-4 10mg
Supplier: Apexbio Technology LLC B778810
MPC 6827 hydrochloride (CAS 917369-31-4) also known as Azixa is a small-molecule microtubule destabilizer that binds to the colchicine site on -tubulin By disrupting microtubule dynamics it induces mitotic arrest at the G2-M phase resulting in apoptotic cell death In preclinical models MPC 6827 has suppressed the growth of various subcutaneously implanted tumor cell lines and demonstrated vascular disruptive activity in human ovarian cancer xenografts Additionally it has shown synergy with carboplatin and inhibited glioblastoma growth in intracranial xenograft models MPC 6827 is utilized in cancer research to elucidate microtubule-targeting mechanisms and investigate tumor biology
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