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Medchemexpress LLC MPP+ iodide | 36913-39-0 | 100.0% | 297.14 | 50 MG
SDP

Supplier:  Medchemexpress LLC HYW00871950MG

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MPP+ iodide is a toxic metabolite of the neurotoxin MPTP. It causes symptoms of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in the substantia nigra. It is taken up by the dopamine transporter into dopaminergic neurons, where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high-affinity substrate for the serotonin transporter (SERT).

  • Toxic metabolite of neurotoxin MPTP.
  • Causes Parkinson's disease symptoms in animal models.
  • Selectively destroys dopaminergic neurons in substantia nigra.
  • Taken up by dopamine transporter into dopaminergic neurons.
  • Exerts neurotoxic action on mitochondria by affecting complex I of the respiratory chain.
  • High-affinity substrate for the serotonin transporter (SERT).

Catalog No. 50-004-52654


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