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Medchemexpress LLC Mpp+ (iodide) | 36913-39-0 | 99.9% | 297.14 | 10 MG
Supplier: Medchemexpress LLC HYW00871910MG
MPP+ iodide is a toxic metabolite of the neurotoxin MPTP. It causes symptoms of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in the substantia nigra. The compound is absorbed by the dopamine transporter into dopaminergic neurons, where it exerts neurotoxic action on mitochondria by affecting complex I of the respiratory chain. It is also a high-affinity substrate for the serotonin transporter (SERT).
- Purity: 99.96%
- Appearance: Solid, light yellow to yellow
- Shipping: Room temperature (continental US)
- Storage: 4°C (sealed, moisture/light protected); in solvent -80°C (6 months) or -20°C (1 month)
- Solubility (H2O/DMSO): 100 mg/mL (ultrasonic needed)
- Research use only
- Inhibits NADH-linked respiration, impairs aerobic glycolysis, causes neurotoxicity
- Documentation available: Data sheet, COA, SDS, handling instructions
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