Sigma Aldrich Fine Chemicals Biosciences Mpro 3CL Protease from cor

Supplier:  Sigma Aldrich Fine Chemicals Biosciences SAE0172200UG

Mpro 3CL is a critical enzyme for the virus life cycle. It activity yield non-structural proteins that are crucial for genome replication and Coronavirus virion production RNA-dependent RNA polymerase a helicase ribonucleases and 3CLpro itself from two types of polyproteins (pp1a and pp1ab).The maturation of SARS-Cov2 virus (SARS coronavirus) depends on cleavage of the overlapping large polyproteins 1a and 1ab by two viral proteases Mpro (main protease) PLpro (Papain-like protease)SARS-CoV Mpro 3CL exists as a homodimer and each protomer has an active site. The proteolytic cleavage of 1ab polyprotein by Mpro occurs at 11 sites 7 sites within the 1a polyprotein and 11 sites within the 1ab polyprotein. This results in maturation of 16 viral non-structural proteins.Mpro protease forms a functional homodimer. Both the N-terminus and the C- terminus of Mpro have been shown to be critical for dimer formation and for enzyme function. The Mpro protease 3CLpro is an ideal targ

Catalog No. 50-290-5108