Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC MRT67307 HCl 2095432-39-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A36355.1
MRT67307 HCl (CAS 2095432-39-4) is a small-molecule inhibitor targeting several kinases including TBK1 IKK MARK1-4 NUAK1 ULK1/2 and salt-inducible kinases (SIK1-3) It inhibits TBK1 and IKK to block phosphorylation of IRF3 reducing interferon- synthesis without affecting NF- B activation Additionally MRT67307-mediated SIK inhibition promotes regulatory macrophage differentiation leading to elevated anti-inflammatory cytokines (e g IL-10 IL-1ra) and decreased pro-inflammatory cytokines (IL-6 IL-12 TNF) It is utilized to investigate innate immunity macrophage polarization autophagy and inflammation pathways
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?