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TARGETMOL CHEMICALS INC MRTX-1257 5MG
SDP

Catalog No. 502577343
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Also available in 1mg 2mg 10mg 25mg 50mg 100mg and bulk. Please contact Fisher for quotes. MRTX-1257 is a selective irreversible and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX1257 demonstrated 31% bioavailability in the mouse with free fraction exposures well above the cellular potency In a PK/PD experiment 77% target engagement. purity: 99%

Catalog No. 50-257-7343 Supplier TARGETMOL CHEMICALS INC Supplier No. T161435MG
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Also available in 1mg 2mg 10mg 25mg 50mg 100mg and bulk. Please contact Fisher for quotes. MRTX-1257 is a selective irreversible and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX1257 demonstrated 31% bioavailability in the mouse with free fraction exposures well above the cellular potency In a PK/PD experiment 77% target engagement. purity: 99%

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