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Medchemexpress LLC MRTX-EX185 formic | 2988148-70-3 | 97.23% | C34H35FN6O4 | 1 MG
SDP

Supplier:  Medchemexpress LLC HY145962A1MG

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MRTX-EX185 formic is a potent KRAS (G12D) inhibitor (IC50 of 90 nM) that binds to both GDP-loaded and active GNP states of KRAS. It exhibits broad-spectrum binding properties and is used for studying various RAS-driven tumors, such as pancreatic cancer.

  • Potent KRAS (G12D) inhibitor with IC50 of 90 nM
  • Binds to GDP-loaded and active GNP states of KRAS and KRAS (G12D)
  • Exhibits broad-spectrum binding properties including for KRAS WT, G12C, Q61H, G13D, and HRAS
  • Suppresses cell proliferation in KRAS (G12D)-driven SW-1990 pancreatic cancer cells (IC50 = 70 nM)
  • Non-toxic to non-KRAS-dependent HEK293 cells
  • Significantly inhibits ERK phosphorylation in KRAS(G12C)-driven cell lineages

Catalog No. 50-003-53971


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