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Medchemexpress LLC MRTX-EX185 formic | 2988148-70-3 | 97.23% | C34H35FN6O4 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY145962A10MM/1ML

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MRTX-EX185 formic is a potent KRAS (G12D) inhibitor with an IC50 of 90 nM. It binds to both GDP-loaded and active GNP states of KRAS and KRAS (G12D). This compound exhibits broad-spectrum binding properties and can be utilized for studying various RAS-driven tumors, such as pancreatic cancer.

  • Suppresses cell proliferation in KRAS (G12D)-driven SW-1990 pancreatic cancer cells with an IC50 of 70 nM.
  • Non-toxic to non-KRAS-dependent cell lines (HEK293 cells).
  • Significantly inhibits ERK phosphorylation (p-ERK) in KRAS(G12C)-driven cell lineages.

Catalog No. 50-003-53970


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