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Medchemexpress LLC MRTX9768 | 2629314-68-5 | 99.48% | 424.43 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY13868450MG

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MRTX9768 is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor. It inhibits SDMA and cell proliferation in HCT116 MTAP-del cells with marked selectivity over HCT116 MTAP-WT cells. This compound selectively targets MTAP/CDKN2A-deleted tumors, such as glioblastoma, and exhibits a favorable ADME profile.

  • Potent and selective PRMT5-MTA complex inhibitor
  • Inhibits SDMA and cell proliferation in MTAP-del cells
  • Demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors
  • Selectively targets MTAP/CDKN2A-deleted tumors, including glioblastoma
  • Favorable ADME profile with high bioavailability and moderate to high clearance

Catalog No. 50-003-50342


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