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Medchemexpress LLC MS-444 | 150045-18-4 | 98.75% | 230.22 | 5 MG
Supplier: Medchemexpress LLC 5MGHY100685
MS-444 is an inhibitor of purified smooth muscle myosin light chain kinase (MLCK) with an IC50 value of 10 μM. It also functions as a small molecule RNA-binding protein HuR (ELAVL1) inhibitor, demonstrating growth inhibition in colorectal cancer cells and anti-angiogenic potential in vivo. This product is for research use only and not intended for patient use.
- Inhibits smooth muscle myosin light chain kinase (MLCK) with an IC50 of 10 μM.
- Functions as a small molecule RNA-binding protein HuR (ELAVL1) inhibitor.
- Demonstrates growth inhibition in various colorectal cancer cell lines.
- Less responsive in non-transformed intestinal epithelial cells compared to cancer cells.
- Shows anti-tumor effects and reduces microvessel density in vivo in xenograft models.
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