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AdipoGen MSA-2
SDP

Supplier:  AdipoGen AGCR10164M001

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Chemical. CAS 129425-81-6. Formula C14H14O5S. MW 294.3. MSA-2 is a new orally available non-nucleotide STING STimulator of INterferon Genes agonist, with EC50s of 8.3 and 24µM for human STING isoforms WT and HAQ. Activation of the STING protein by its natural ligand, cyclic guanosine monophosphate-adenosine monophosphate cGAMP, a cytosolic double-stranded DNA sensor, triggers signaling responses, inducing the release of type I interferons and other proinflammatory cytokines. STING-controlled interferon production is involved in antiviral defense as well as antitumor immunity. Pharmacological activation of STING is considered a promising therapeutic strategy for cancer. MSA-2 highly induces secretion in vitro of IFN-beta from THP-1 cells and mouse macrophages at concentration of 10-50µM.

Catalog No. 50-256-2352


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