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Medchemexpress LLC MSA-2 | 129425-81-6 | 99.8% | 294.32 | 200 MG
SDP

Supplier:  Medchemexpress LLC HY136927200MG

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MSA-2 is a potent and orally available non-nucleotide STING agonist that binds to STING as a noncovalent dimer with nanomolar affinity. It stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models.

  • Potent and orally available non-nucleotide STING agonist
  • Binds to STING as a noncovalent dimer with nanomolar affinity
  • Stimulates interferon-β secretion in tumors
  • Induces tumor regression with durable antitumor immunity
  • Synergizes with anti-PD-1 in syngeneic mouse tumor models
  • Achieves comparable exposure in tumor and plasma
  • Exhibits dose-dependent antitumor activity
  • Induces elevations of IFN-β, IL-6, and TNF-α in tumors

Catalog No. 50-003-48703


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