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Cayman Chemical MSH ReleaseInhIbItng Factr
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Supplier:  Cayman Chemical 24476100 MG

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A synthetic peptide GnRHR antagonist (Kd 0.2 nM) inhibits [D-Trp6]GnRH-induced activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells (IC50 1.2 nM) reduces tumor volume and serum luteinizing hormone levels by 35 and 50 of control respectively in a human epithelial ovarian cancer mouse xenograft model at 60 g per day increases PMF survival in ovaries in cyclophosphamide treated mice at 0.5 mg/kg

Catalog No. 50-293-6532


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