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Medchemexpress LLC MSI-1436 lactate | 1309370-86-2 | 98.8% | 1000.17 | 5 MG
SDP

Catalog No. 5000364089
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MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM, demonstrating a 200-fold preference over TCPTP (IC50 of 224 μM). It is intended for research use only and not for sale to patients.

  • Selective, non-competitive inhibitor of PTP1B
  • 200-fold preference over TCPTP
  • Restores ERK phosphorylation in F11 neuronal cells.
  • Rescues DHPG-induced holding currents and restores DSI in LMO4KO BLA neurons.
  • Blocks PTP1B activity (0.1-100 μM).
  • Reduces obesity-dependent body weight, total body fat, and adipocyte size in mice (10 mg/kg, i.p.).
  • Exhibits anxiolytic effect via endocannabinoid (eCB) signaling in amygdala.
  • Anti-diabetic effect in mice, suppresses food intake and causes weight loss (5 mg/kg, i.p.).

Catalog No. 50-003-64089 Supplier Medchemexpress LLC Supplier No. 5MGHY12219A
May include imposed supplier surcharges.
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MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM, demonstrating a 200-fold preference over TCPTP (IC50 of 224 μM). It is intended for research use only and not for sale to patients.

  • Selective, non-competitive inhibitor of PTP1B
  • 200-fold preference over TCPTP
  • Restores ERK phosphorylation in F11 neuronal cells.
  • Rescues DHPG-induced holding currents and restores DSI in LMO4KO BLA neurons.
  • Blocks PTP1B activity (0.1-100 μM).
  • Reduces obesity-dependent body weight, total body fat, and adipocyte size in mice (10 mg/kg, i.p.).
  • Exhibits anxiolytic effect via endocannabinoid (eCB) signaling in amygdala.
  • Anti-diabetic effect in mice, suppresses food intake and causes weight loss (5 mg/kg, i.p.).

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