Medchemexpress LLC MSI-1436 lactate | 1309370-86-2 | 98.8% | 1000.17 | 5 MG

Supplier:  Medchemexpress LLC 5MGHY12219A

MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM, demonstrating a 200-fold preference over TCPTP (IC50 of 224 μM). It is intended for research use only and not for sale to patients.

• Selective, non-competitive inhibitor of PTP1B
• 200-fold preference over TCPTP
• Restores ERK phosphorylation in F11 neuronal cells.
• Rescues DHPG-induced holding currents and restores DSI in LMO4KO BLA neurons.
• Blocks PTP1B activity (0.1-100 μM).
• Reduces obesity-dependent body weight, total body fat, and adipocyte size in mice (10 mg/kg, i.p.).
• Exhibits anxiolytic effect via endocannabinoid (eCB) signaling in amygdala.
• Anti-diabetic effect in mice, suppresses food intake and causes weight loss (5 mg/kg, i.p.).

Catalog No. 50-003-64089