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Apexbio Technology LLC MTT(Synonyms: Thiazolyl Blue Tetrazolium Bromide, Methylthiazolyldiphenyl-tetrazolium bromide), 500mg, CAS: 298-93-1.
Supplier: Apexbio Technology LLC B7777500
MTT (CAS 298-93-1) chemically known as 3-(4 5-Dimethylthiazol-2-yl)-2 5-diphenyl-2H-tetrazolium bromide is a tetrazolium salt commonly employed in biomedical research to assess cellular proliferation and metabolic activity in vitro Upon uptake by viable cells MTT undergoes reduction primarily mediated by NADH-dependent oxidoreductases in mitochondria and partly by extra-mitochondrial enzymes forming insoluble formazan precipitates The resulting formazan accumulation correlates with metabolic activity and cell viability Due to its membrane-permeable cationic nature MTT efficiently penetrates intact cell membranes without requiring intermediates distinguishing it from second-generation negatively charged tetrazolium derivatives
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