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ABclonal Technology MUC16/CA125 Rabbit mAb
Supplier: ABclonal Technology A2545520UL
This gene encodes a membrane-tethered mucin protein involved in forming a protective mucous barrier on epithelial surfaces The protein has an extracellular domain at its amino terminus a large tandem repeat region rich in serines threonines and prolines and a transmembrane domain with a short cytoplasmic tail The repeat region includes SEA (Sea urchin sperm protein Enterokinase and Agrin) leucine-rich and ankyrin repeats forming the ectodomain A potential cleavage site is near an SEA module This protein is believed to protect epithelial cells from pathogens It is used as a cancer marker with higher expression linked to poorer outcomes
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