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AdipoGen MultimericCD40L hAnim-Free
Supplier: AdipoGen AG40B0010AFC010
Recombinant protein. Human CD40L aa 116-261 is fused at the N-terminus to mouse ACRP30headless aa 18-111 and a FLAG -tag. Source CHO cells. Produced using animal component-free medium. Lyophilized. Contains PBS Induces B cell activation as demonstrated by dose-dependent upregulation of CD86 ED50 <1ng/ml. B cell expansion online protocol available. CD40 ligand CD40L expressed by activated T cells engages CD40 expressed by B cells and APCs. CD40L can provide signals to B cells that induce proliferation, immunoglobulin class switching and antibody secretion. CD40L has been used recently in Immunotherapy to activate tumor-infiltrated lymphocytes TIL. MultimericCD40L™ is a high-activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to combinations. Mul
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