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Invivogen MURAMYLDIPEPTIDE (L ISOFORM)-
Supplier: Invivogen TLRLMDP
Muramyl dipeptide (MDP) is the minimal bioactive peptidoglycan motif common to all bacteria, the essential structure required for adjuvant activity in vaccines. MDP has been shown to be recognized by NOD2, but not TLR2, nor TLR2/1 or TLR2/6 associations [1, 2]. This recognition is highly stereospecific of the L-D isomer, excluding any reaction to the D-D or L-L analogs [2]. The potent adjuvant activity of MDP may be linked to an activation of the CIAS1/NALP3/Cryopyrin inflammasome [3]. Specificity: NOD2 agonist Working concentration: 10 ng - 10 ug/ml CAS number: 53678-77-6 Solubility: 10 mg/ml in water Formula: C19H32N4O11 Molecular weight: 492.
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