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Medchemexpress LLC MYC degrader 1 (compound A80.2HCl) | 2946670-96-6 | 99.6% | 626.07 | 1 MG
SDP

Supplier:  Medchemexpress LLC HY1623181MG

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MYC degrader 1 (compound A80.2HCl) is an orally available MYC molecular glues degrader that demonstrates anti-tumor activity. It works by restoring pRB1 protein activity and re-establishing the sensitivity of MYC-overexpressing cancer cells to CDK4/6 inhibitors.

  • Degrades MYC in various cell lines.
  • Reduces the IC50 of Palbociclib in T24 and UMUC14 cells.
  • Enhances the inhibition of cell cycle genes and colony formation by Palbociclib in drug-resistant cancer cell lines.
  • Inhibits the growth of T24 and UMUC14 xenograft tumors in mice.
  • Enhances the inhibitory effect of Palbociclib on tumor growth in T24 xenograft mice.

Catalog No. 50-003-94591


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