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Medchemexpress LLC MYF-01-37 | 2416417-65-5 | 99.4% | 298.30 | 100 MG
Supplier: Medchemexpress LLC HY139603100MG
MYF-01-37 is a covalent TEAD inhibitor that targets Cys380. It exhibits reversible inhibition on YAP/TEAD interaction and is intended for research use only, not for sale to patients. In vitro studies show that MYF-01-37 inhibits direct YAP/TEAD interaction in HEK 293T cells and reduces canonical YAP target gene CTGF expression in PC-9 cells.
- Covalent TEAD inhibitor targeting Cys380
- Reversible inhibition on YAP/TEAD interaction
- Inhibits direct YAP/TEAD interaction in HEK 293T cells
- Reduces canonical YAP target gene CTGF expression in PC-9 cells
- Minimal impact on cell viability of several EGFR-mutant NCSLC cell lines
- Decreases dormant cells when combined with other treatments
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