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Medchemexpress LLC Myf-01-37 | 2416417-65-5 | 99.44% | 298.30 | 50 MG
Supplier: Medchemexpress LLC HY13960350MG
MYF-01-37 is a covalent TEAD inhibitor that targets Cys380 and demonstrates a reversible inhibition of the YAP/TEAD interaction. It has minimal impact on the cell viability of several EGFR-mutant NCSLC cell lines and, when combined with osimertinib and trametinib, leads to a significant decrease in dormant cells. This product is intended for research use only.
- Inhibits direct YAP/TEAD interaction in HEK 293T cells
- Reduces canonical YAP target gene CTGF expression in PC-9 cells
- Minimal impact on cell viability of EGFR-mutant NCSLC cell lines
- Decreases dormant cells when combined with OT
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