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Medchemexpress LLC MYF-03-176 | 2857937-59-6 | 99.7% | 410.37 | 1 ML
SDP

Catalog No. 5000361650
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MYF-03-176 is an orally active inhibitor of TEAD, and suppresses TEAD transcriptional activity with an IC50 of 11 nM. The IC50 values of MYF-03-176 for TEAD1, TEAD3, and TEAD4 are 47, 32, and 71 nM, respectively. MYF-03-176 inhibits hippo signaling defective malignant pleural mesothelioma (MPM) cells. MYF-03-176 shows strong antitumor efficacy in MPM mouse xenograft model.

  • IC50 and target: IC50: TEAD1 (47 nM), TEAD2 (275 nM), TEAD3 (32 nM), TEAD4 (71 nM)
  • Cellular effect (NCI-H226): IC50 24 nM. Antiproliferative activity against human NCI-H226 cells assessed as reduction in cell viability measured for 5 days by CellTiter-Glo assay.

Catalog No. 50-003-61650 Supplier Medchemexpress LLC Supplier No. HY14713610MM/1ML
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MYF-03-176 is an orally active inhibitor of TEAD, and suppresses TEAD transcriptional activity with an IC50 of 11 nM. The IC50 values of MYF-03-176 for TEAD1, TEAD3, and TEAD4 are 47, 32, and 71 nM, respectively. MYF-03-176 inhibits hippo signaling defective malignant pleural mesothelioma (MPM) cells. MYF-03-176 shows strong antitumor efficacy in MPM mouse xenograft model.

  • IC50 and target: IC50: TEAD1 (47 nM), TEAD2 (275 nM), TEAD3 (32 nM), TEAD4 (71 nM)
  • Cellular effect (NCI-H226): IC50 24 nM. Antiproliferative activity against human NCI-H226 cells assessed as reduction in cell viability measured for 5 days by CellTiter-Glo assay.

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